Tagline: Thermostabilization of PPR vaccine
Champion: Richard Bishop and Jeff Mariner
Team: The ASF component of the vaccine development platform, LSE, LGI
Peste des petits ruminants (PPR) is a contagious, acute viral and economically important disease of sheep and goats that is caused by the virus of the genus Morbillivirus and is characterised by high mortality (Furley, et al. 1987 Vet Rec 121(19): 443-447). ILRI is among the institutions that are committed to having the burden of PPR to livestock and the livelihoods of the farmers reduced through research, most notably in the quest for a thermostable vaccine against the disease. Below is a summary of the status of PPR research at ILRI: A key advantage of the project is that it starts from adaptive laboratory research but goes all the way to an outcome and potentially ultimately impact on the livelihoods of pastoralist who are dependent on small ruminants in many areas.
- Re-confirm the initial protocol developed by Jeff Mariner using improved Vero Dog SLAM cells for PPR propagation
- Validate product in collaboration with morbillivirus OIE world reference centre Pirbright
- Test the thermostable product for protection in small ruminantss in vivo
- Scale up with suitable commercial partner, if proof of concept is confirmed
- Collaborate with others both within and outside ILRI (including Jeff Mariner) for product delivery in the field (Northern Uganda/Southern Sudan
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